Genetic and environmental influences on early speech, language and literacy development

from the Journal of Communication Disorders

The genetic and environmental etiology of speech and broader language skills was examined in terms of their concurrent relationships in young children; their longitudinal association with reading; and the role they play in defining the ‘heritable phenotype’ for specific language impairment (SLI). The work was based on a large sample of 4 1/2-year-old twins, who were assessed at home on a broad range of speech and language measures as part of the Twins Early Development Study. We found that genetic factors strongly influence variation in young children’s speech in typical development as well as in SLI, and that these genetic factors also account for much of the relationship between early speech and later reading. In contrast, shared environmental factors play a more dominant role for broader language skills, and in relating these skills to later reading; isolated impairments in language as opposed to speech appear to have largely environmental origins.

Vocal Fold Self-Disruption After Phonotrauma On A Lead Actor: A Case Presentation

from the Journal of Voice

Summary
It is well known that phonotraumatic events may produce laryngeal inflammation, vocal fold hemorrhage and different types of mass lesions. This study describes a vocal fold self-disruption that occurred on stage to a lead actor in the role of Richard III. The study design is as case presentation. A 43-year-old actor presented with a sudden voice loss that first occurred on stage after a series of presentations. He also had a cold-like condition that had not been treated. His past medical history included an average of ten cigarettes per day for ten years and a 10-year history of gastritis and stomach ulcer. Perceptual, acoustic, and laryngeal analyses were performed following pharmacological and voice therapy. Perceptual and acoustic analyses showed mild deviations whereas laryngeal visual examination revealed a complete right vocal fold detachment from the anterior commissure to the vocal process, with generalized hyperemia. A mild diffuse Reinke’s edema was observed on the left vocal fold. Mild discomfort was present only during the first day of the acute period. Modified vocal rest was recommended and a series of vocal exercises were administered. The patient performed again 4 days later, after following a series of behavioral modification techniques that included casting guidelines during the subsequent 15 days. Healing was exceptional and his voice returned to normal. This unique case with an exceptional recovery emphasizes the etiological aspects of scar formation after phonotrauma. Positive contributing factors may include a good vocal technique and adequate training as well as the protective upregulated genes present in Reinke’s edema.

Perispinal etanercept produces rapid improvement in primary progressive aphasia: identification of a novel, rapidly reversible tnf-mediated pathophysiologic mechanism

fromMediscape.com

No abstract available.

Implant cochléaire et développement des échanges conversationnels. / Cochlear implant and development of conversational exchanges

from the Canadian Journal of Behavioural Science

Most researches conducted in the field of postimplant assessment have focused on the restoration of perceptual capabilities and the development of verbal language. In contrast, only very few studies have examined the impact of a cochlear implantation on children’s overall development and, in particular, on their conversational language abilities. However, some previous works on the preverbal development revealed the recurrent difficulties experienced by deaf children in acquiring knowledge of social rules and social skills relative to speech activities. In children with profound bilateral deafness, a conventional hearing aid is not enough to provide sufficiently relevant information for a satisfactory development of oral communication. In such situations, the most suitable way of improving hearing is the use of a cochlear implant. The authors therefore hypothesized that access to oral perception will not only improve implanted children’s social skills, but will also increase their rate of participation and the use of verbal language in their interaction with a familiar adult (mother or father). Their communication skills profile would resemble that of younger normal hearing children. Using conversational samples from a video-filming protocol at specific intervals, the authors monitored the development of communication skills in a group of 20 prelingually, profoundly deaf children (mean age: 3.7 years). Results corroborated our hypothesis. They indicated that children using cochlear implants increased their overall performance in communication skills, quantitatively and qualitatively speaking, even at the first year postimplantation stage. (PsycINFO Database Record (c) 2008 APA, all rights reserved)

Don’t pump up the volume: Australian research

from Reuters

Next time you crank up the volume, beware: an Australian government report said young people risk developing permanent hearing problems if they go to noisy bars and listen to loud music through headphones.

The report, released on Tuesday, found two out of three Australians suffered some degree of hearing damage, but 70 percent of people aged 18 to 34 years had reported ringing in their ears, or tinnitus, which can be a sign of permanent damage.

Commentary on “Occupational Noise, Smoking and a High Body Mass Index are Risk Factors for Age-Related Hearing Impairment and Moderate Alcohol Consumption is Protective: a European Population-Based Multicentre Study” by Fransen et al., J. Assoc. Res. Otolaryngol. DOI 10.1007/s10162-008-0123-1

from JARO — Journal of the Association for Research in Otolaryngology

No abstract available.

Cultural route to the emergence of linguistic categories

from the Proceedings of the National Academy of Sciences of the United States of America

Categories provide a coarse-grained description of the world. A fundamental question is whether categories simply mirror an underlying structure of nature or instead come from the complex interactions of human beings among themselves and with the environment. Here, we address this question by modeling a population of individuals who co-evolve their own system of symbols and meanings by playing elementary language games. The central result is the emergence of a hierarchical category structure made of two distinct levels: a basic layer, responsible for fine discrimination of the environment, and a shared linguistic layer that groups together perceptions to guarantee communicative success. Remarkably, the number of linguistic categories turns out to be finite and small, as observed in natural languages.

An MRI-based diagnostic framework for early diagnosis of dyslexia

from the International Journal of Computer Assisted Radiology and Surgery

Abstract
Purpose A computer-aided diagnosis (CAD) system for early diagnosis of dyslexia was developed and tested. Dyslexia can severely impair the learning abilities of children so improved diagnostic methods are needed. Neuropathological studies show abnormal anatomy of the cerebral white matter (CWM) in dyslexic brains. We sought to develop an MRI-based macroscopic neuropathological correlate to the minicolumnopathy of dyslexia that relates to cortical connectivity: the gyral window. The brains of dyslexic patients often exhibit decreased gyrifications, so the thickness of gyral CWM for dyslexic subjects is greater than for normal subjects. We developed an MRI-based method for assessment of gyral CWM thickness with automated recognition of abnormal (e.g., dyslexic) brains.
Methods In vivo data was collected from 16 right-handed dyslexic men aged 18–40 years, and a group of 14 controls matched for gender, age, educational level, socioeconomic background, handedness and general intelligence. All the subjects were physically healthy and free of history of neurological diseases and head injury. Images were acquired with the same 1.5T MRI scanner (GE, Milwaukee, WI, USA) with voxel resolution 0.9375 × 0.9375 × 1.5 mm using a T1-weighted imaging sequence protocol. The “ground truth” diagnosis to evaluate the classification accuracy for each patient was given by the clinicians. The accuracy of diagnosis/classification of both the training and test subjects was evaluated using the Chi-square test at the three confidence levels—85, 90 and 95%—in order to examine significant differences in the Levy distances.
Results As expected, the 85% confidence level yielded the best results, the system correctly classified 16 out of 16 dyslexic subjects (a 100% accuracy) and 14 out of 14 control subjects (a 100% accuracy). At the 90% confidence level, 16 out of 16 dyslexic subjects were still classified correctly; however, only 13 out of 14 control subjects were correct, bringing the accuracy rate for the control group down to 92.86%. The 95% confidence level obviously gives the smaller accuracy rates for both the groups, namely, 14 out of 16 correct answers for dyslexic subjects (87.5%) and still 13 out of 14 control subjects (92.86%). The classification based on traditional volumetric approach is 7 out of 16 dyslexic subjects (a 43.75% accuracy), and 9 out of 14 control subjects (a 64.29% accuracy) at a 85 confidence interval. These results highlight the advantage of the proposed diagnostic approach.
Conclusion We found that 3D texture analysis of MRI brain scans can accurately discriminate dyslexic and normal subjects in this feasibility trial. Our method for white matter segmentation and classification outperforms volumetric descriptions of brain structures and may be influenced less by age effects and segmentation errors. The proposed approach efficiently extracts quantitative features from 3D shapes of brain structures.

Occupational Noise, Smoking, and a High Body Mass Index are Risk Factors for Age-related Hearing Impairment and Moderate Alcohol Consumption is Protective: A European Population-based Multicenter Study

from JARO — Journal of the Association for Research in Otolaryngology

Abstract A multicenter study was set up to elucidate the environmental and medical risk factors contributing to age-related hearing impairment (ARHI). Nine subsamples, collected by nine audiological centers across Europe, added up to a total of 4,083 subjects between 53 and 67 years. Audiometric data (pure-tone average [PTA]) were collected and the participants filled out a questionnaire on environmental risk factors and medical history. People with a history of disease that could affect hearing were excluded. PTAs were adjusted for age and sex and tested for association with exposure to risk factors. Noise exposure was associated with a significant loss of hearing at high sound frequencies (>1 kHz). Smoking significantly increased high-frequency hearing loss, and the effect was dose-dependent. The effect of smoking remained significant when accounting for cardiovascular disease events. Taller people had better hearing on average with a more pronounced effect at low sound frequencies (<2 kHz). A high body mass index (BMI) correlated with hearing loss across the frequency range tested. Moderate alcohol consumption was inversely correlated with hearing loss. Significant associations were found in the high as well as in the low frequencies. The results suggest that a healthy lifestyle can protect against age-related hearing impairment.
Electronic supplementary material The online version of this article (doi: 10.1007/s10162-008-0123-1) contains supplementary material, which is available to authorized users.

Tune-deaf people may hear a sour note unconsciously

from EurekAlert.org

People with tune deafness aren’t able to tell when a musician accidentally strikes the wrong note in a song, but their brains know the difference. Researchers from the National Institute on Deafness and Other Communication Disorders (NIDCD), part of the National Institutes of Health, have found that people with tune deafness, an auditory processing disorder in which a person with normal hearing has trouble distinguishing notes in a melody, are able to detect a wrong note unconsciously. The study is published in the June 11, 2008, issue of the online journal PLoS ONE (http://www.plosone.org/doi/pone.0002349).

Tract-Based Spatial Statistics of Diffusion Tensor Imaging in Adults with Dyslexia

from the AJNR – American Journal of Neuroradiology

BACKGROUND AND PURPOSE: Diffusion tensor imaging is a tool that can be used to study white matter microstructure in dyslexia. We tested the hypothesis that dyslexics have a white matter structural change (as measured by directional diffusion of water, which can be affected by disruption in white matter tracts) between brain regions that previous functional connectivity studies showed were associated with phonologic processing.

MATERIALS AND METHODS: Diffusion tensor imaging (DTI) scans were acquired from 7 healthy adult normal readers and from 14 adults with dyslexia on a 1.5T scanner. Voxelwise statistical analysis of the fractional anisotropy data were carried out by using Tract-Based Spatial Statistics to compare dyslexic subjects versus control subjects in white matter tracts.

RESULTS: Significant group difference map clusters (comparing adults with and without dyslexia) occurred in specific bilateral white matter tracts within the frontal lobe, temporal lobe, occipital lobe, and parietal lobe.

CONCLUSION: The DTI fractional anisotropy results in the bilateral white matter showing higher fractional anisotropy in adult control subjects compared with adults with dyslexia (relating to white matter fiber tract integrity) are consistent with our previous functional connectivity results from seed points in the bilateral inferior frontal gyrus.

Smoking link to hearing loss risk

from the BBC

Smoking and obesity could both cause permanent hearing damage, say scientists.

American Sign Language syntactic and narrative comprehension in skilled and less skilled readers: Bilingual and bimodal evidence for the linguistic basis of reading

from Applied Psycholinguistics

We tested the hypothesis that syntactic and narrative comprehension of a natural sign language can serve as the linguistic basis for skilled reading. Thirty-one adults who were deaf from birth and used American Sign Language (ASL) were classified as skilled or less skilled readers using an eighth-grade criterion. Proficiency with ASL syntax, and narrative comprehension of ASL and Manually Coded English (MCE) were measured in conjunction with variables including exposure to print, nonverbal IQ, and hearing and speech ability. Skilled readers showed high levels of ASL syntatic ability and narrative comprehension whereas less skilled readers did not. Regression analyses showed ASL syntactic ability to contribute unique variance in English reading performance when the effects of nonverbal IQ, exposure to print, and MCE comprehension were controlled. A reciprocal relationship between print exposure and sign language proficiency was further found. The results indicate that the linguistic basis of reading, and the reciprocal relationship between print exposure and “through the air” language, can be bimodal, as in being a sign language or a spoken language, and bilingual, as in being ASL and English.

Determining language dominance in English–Mandarin bilinguals: Development of a self-report classification tool for clinical use

from Applied Psycholinguistics

In multilingual Asian communities, determining language dominance for clinical assessment and intervention is often complex. The aim of this study was to develop a self-report classification tool for identifying the dominant language in English–Mandarin bilinguals. Participants (N = 168) completed a questionnaire on language history and single-word receptive vocabulary tests (Peabody Picture Vocabulary Test type) in both languages. The results of a discriminant analysis on the self-report data revealed a reliable three-way classification into English-dominant, Mandarin-dominant, and balanced bilinguals. The vocabulary scores supported these dominance classifications, whereas the more typical variables such as age of first exposure, years of formal instruction, and years of exposure exerted only a limited influence. The utility of this classification tool in clinical settings is discussed.

Elicitation of the passé composé in French preschoolers with and without specific language impairment

from Applied Psycholinguistics

This study examines inflectional abilities in French-speaking children with specific language impairment (SLI) using a verb elicitation task. Eleven children with SLI and age-matched controls (37–52 months) participated in the experiment. We elicited the passé composé using eight regular and eight irregular high frequency verbs matched for age of acquisition. Children with SLI showed dissimilar productive verb inflection abilities to control children (even when comparing participants with similar verb vocabularies and mean length of utterance in words). Control children showed evidence of overregularization and sensitivity to morphological structure, whereas no such effects were observed in the SLI group. Error patterns observed in the SLI group demonstrate that, at this age, they cannot produce passé composé forms in elicitation tasks, even though some participants used them spontaneously. Either context by itself might therefore be insufficient to fully evaluate productive linguistic abilities in children with SLI.