Monthly Archives: July 2010
Cortical neuroanatomic correlates of symptom severity in primary progressive aphasia
Conclusions: The PASS, a novel measure of the severity of clinical impairment within domains of language typically affected in PPA, demonstrates reliable and valid clinical-behavioral properties. Furthermore, the presence of impairment in individual PASS domains demonstrates specific relationships with focal abnormalities in particular brain regions and the severity of impairment is strongly related to the severity of anatomic abnormality within the relevant brain region. These anatomic imaging biomarkers perform well in classifying PPA subtypes. These data provide robust support for the value of this novel clinical measure and the new imaging measure as markers for potential use in clinical research and trials in PPA.
from Neurology
Executive Functions Deficit in Parkinson’s Disease With Amnestic Mild Cognitive Impairment
Recent studies suggest that onset of dementia in Parkinson’s disease (PD) is preceded by a phase known as mild cognitive impairment (MCI). Different clinical subtypes of MCI in PD were found. The objective of this study was to investigate whether patients with PD diagnosed with amnestic MCI (aPD-MCI) have also subtle deficits in other cognitive domains and especially in attention/executive functions and, therefore to clarify whether all subcomponents of executive control are equally affected in aPD-MCI. We investigated 23 patients with aPD-MCI (modified Petersen’s criteria) and 25 normal controls. Relative to controls, the aPD-MCI group showed significant deficits with reference to tasks that encompass various aspects of attention/executive functions, including Trail Making Test, Stroop test, Modified Card Sorting Test, and digit span backward, as well as phonemic and semantic verbal fluency. This suggests that executive dysfunction is consistently presented in PD with MCI, even in ‘‘amnestic’’ PD-MCI due to cortical—subcortical dysfunction.
from the American Journal of Alzheimer’s Disease and Other Dementias
Evaluating Rivastigmine in Mild-to-Moderate Parkinson’s Disease Dementia Using ADAS-Cog Items
Rivastigmine has been shown to improve cognition in patients with Parkinson’s disease dementia (PDD). To further explore the impact of anticholinesterase therapy on PDD, Alzheimer’s Disease Assessment Scale-cognitive subscale (ADAS-cog) items were assessed in a retrospective analysis of a 24-week, double-blind, placebo-controlled trial of rivastigmine. Mean changes from baseline at week 24 were calculated for ADAS-cog item scores and for 3 cognitive domain scores. A total of 362 patients were randomized to 3 to 12 mg/d rivastigmine capsules and 179 to placebo. Patients with PDD receiving rivastigmine improved versus placebo on items: word recall, following commands, ideational praxis, remembering test instructions, and comprehension of spoken language (P < .05), with standardized mean differences ranging from 0.04 to 0.30. Rivastigmine also showed significant effects versus placebo on all domains: memory, language, and praxis. The ADAS-cog is sensitive to broad cognitive changes in PDD. Overall, rivastigmine was associated with improvements on individual cognitive items and general cognitive domains.
from the American Journal of Alzheimer’s Disease and Other Dementias
Reviews: Developing Culturally Sensitive Dementia Caregiver Interventions: Are We There Yet?
Despite evidence of ethnic differences in family caregivers’ experiences, the extent to which caregiver interventions are culturally tailored to address these differences is unknown. A systematic review of literature published from 1980 to 2009 identified: differences in caregiving experiences of African American, Latino, and Chinese American caregivers; psychosocial support interventions in these groups; and cultural tailoring of interventions. Ethnic differences in caregiving occurred at multiple levels (intrapersonal, interpersonal, environmental) and in multiple domains (psychosocial health, life satisfaction, caregiving appraisals, spirituality, coping, self-efficacy, physical functioning, social support, filial responsibility, familism, views toward elders, use of formal services and health care). Only 18 of 47 intervention articles reported outcomes by caregiver ethnicity. Only 11 reported cultural tailoring; 8 were from the Resources for Enhancing Alzheimer’s Caregiver Health (REACH) initiative. Cultural tailoring addressed familism, language, literacy, protecting elders, and logistical barriers. Results suggest that more caregiver intervention studies evaluating systematically the benefits of cultural tailoring are needed.
from the American Journal of Alzheimer’s Disease and Other Dementias
Cost analysis of asymmetric sensorineural hearing loss investigations
A comprehensive ASNHL work-up may not be applicable to all patients. Laboratory serologic tests are highly cost effective in diagnosing treatable causes of ASNHL, such as syphilis and Lyme. Although radiographic imaging with MRI is not as cost effective, its value in detecting for acoustic neuroma is undeniable. Laryngoscope, 2010
from The Laryngoscope
Quality of life of children and their caregivers during an AOM episode: development and use of a telephone questionnaireQuality of life of children and their caregivers during an AOM episode: development and use of a telephone questionnaire
The questionnaire was easy to use during telephone interviews and results suggest good reliability and validity of the different scores to measure AOM severity and QOL of children and their caregivers during an AOM episode.
Olfactory dysfunction, gambling task performance and intracranial lesions after traumatic brain injury.
Objective: To estimate the incidence of olfactory dysfunction across traumatic brain injury (TBI) severity and decision-making deficits with regard to intracranial lesions’ location and laterality. Method: A 1-year prospective study including 115 participants (16–55 years) with mild, moderate, and severe TBI. The Brief Smell Identification Test was used 3 months postinjury with a follow-up testing of olfactory dysfunction at 1 year. The Iowa Gambling Task (IGT) and 3 tasks of the Delis–Kaplan Executive Function System were administered 3-months postinjury. MRI was performed 1-year postinjury and TBI severity groups were then divided with respect to frontal, fronto-temporal, diffuse, and no lesions. Results: The incidence of olfactory dysfunction was estimated to be 22.3% at 3 months and 13.5% at 1 year. No significant differences were found on olfactory dysfunction across TBI severity at either check. Anosmia was identified in 10% with severe TBI and 3% with mild TBI. Olfactory dysfunction was associated with verbal fluency tasks. Repeated-measures analysis of variance revealed no significant effect over blocks on IGT, and no main group or interaction effects regarding TBI severity, lesions’ location, or laterality. IGT performance at 3-months postinjury was deficient in 83% of persons with intracranial lesions and 71% of those without lesions. Conclusions: Olfactory dysfunction is independent of TBI severity, showing improvements in one third of cases from 3- to 12-months postinjury. However, anosmia was related to TBI severity. There is evidence for marked decision-making deficits after TBI, all subgroups performed similarly and failed to develop an advantageous strategy over time. (PsycINFO Database Record (c) 2010 APA, all rights reserved)
from Neuropsychology
Perceptual bias for affective and nonaffective information in asymmetric Parkinson’s disease.
Objective: To relate lateralized impairments of visual perception in Parkinson’s disease to asymmetries in the severity of motor symptoms. Method: Ten patients with worse left-sided motor symptoms (LPD), 15 with worse right-sided (RPD), and 13 healthy age-matched controls (all right-handed) viewed mirror-imaged pairs of emotional chimeric faces, (left side smiling, right neutral, and vice versa), of greyscales (strips whose luminance varied smoothly from black on the left to white on the right, and vice versa) and of gender chimeric faces (left side male, right female, and vice versa). Participants signaled which stimulus appeared happier, brighter, or more feminine, respectively, so showing which side received more attention. Results: For emotional chimeras, controls and LPD showed little bias, whereas RPD showed a strong bias to left hemispace (p = .018, r = .45). Across all patients, this bias was associated with severity of right-sided motor impairment (p = .018, r = .49). The bias was much weaker and insignificant for greyscales (p = .72, r = .14). For gender chimeras, RPD again showed a significantly greater left hemispace bias than did LPD (p = .037, r = .47), although neither patient group differed significantly from controls. Across all patients, this bias correlated with ratio of right-to-left symptom severity (p = .044, r = .48). Conclusions: The left hemispace bias in RPD is greater for facial than for luminance judgments, and is amplified for emotional judgments. Asymmetrical degeneration of the striatum, particularly involving the left side, appears to underlie this deficit in visual processing. (PsycINFO Database Record (c) 2010 APA, all rights reserved)
from Neuropsychology
True memory, false memory, and subjective recollection deficits after focal parietal lobe lesions.
Objective: There is mounting evidence that the posterior parietal cortex (PPC) plays an important role in episodic memory. We previously found that patients with PPC damage exhibit retrieval-related episodic memory deficits. Here we assess whether parietal lobe damage affects episodic memory on a different task: the Deese–Roediger–McDermott (DRM) false-memory paradigm. Methods: Two patients with bilateral PPC damage and a group of matched controls were tested. In Experiment 1, the task was to remember words; in Experiment 2 the task was to remember pictures of common objects. Prior studies have shown that normal participants have high levels of false memory to words, low levels to pictures. Results: The patients exhibited significantly lower levels of false memory to words. One patient showed significantly elevated levels of false memory to pictures. The patients’ false memories were accompanied by reduced levels of recollection, as tested by a Remember/Know procedure. Conclusions: PPC damage causes decreased levels of false memories and an abnormal Remember/Know profile. Their false memory rate is similar to the rate exhibited by patients with medial temporal lobe damage. These results support the view that portions of the PPC play a critical role in objective and subjective aspects of recollection. (PsycINFO Database Record (c) 2010 APA, all rights reserved)
from Neuropsychology
How to correct a task error: Task-switch effects following different types of error correction.
It has been proposed that switch costs in task switching reflect the strengthening of task-related associations and that strengthening is triggered by response execution. The present study tested the hypothesis that only task-related responses are able to trigger strengthening. Effects of task strengthening caused by error corrections were considered. Recent findings suggest that errors lead to erroneous task strengthening, which, however, can be reversed by immediate error correction (Steinhauser & Hübner, 2006). In three experiments, the present study examined whether this effect is also obtained when task responses and correction responses share the same response categories but are assigned to different hands or different response modalities (manual vs. vocal). Results indicated that only corrections with the same hand but not corrections with the alternative hand or a different response modality can reverse erroneous task strengthening. These results suggest that only the execution of task-related responses triggers task strengthening, whereas the activation of task-related response categories is not sufficient. (PsycINFO Database Record (c) 2010 APA, all rights reserved)
from Journal of Experimental Psychology: Learning, Memory, and Cognition
Aging and directed forgetting in episodic memory: A meta-analysis.
In this meta-analysis, we examined the effects of aging on directed forgetting. A cue to forget is more effective in younger (d = 1.17) than in older (d = 0.81) adults. Directed-forgetting effects were larger (a) with the item method rather than with the list method, (b) with longer presentation times, (c) with longer postcue rehearsal times, (d) with single words rather than with verbal action phrases as stimuli, (e) with shorter lists, and (f) when recall rather than recognition was tested. Age effects were reliably larger when the item method was used, suggesting that these effects are mainly due to encoding differences. (PsycINFO Database Record (c) 2010 APA, all rights reserved)
from Psychology and Aging
Does speech rhythm sensitivity predict children’s reading ability 1 year later?.
There is a growing literature demonstrating that speech rhythm sensitivity is related to children’s reading development, independent of phonological awareness. However, the precise nature of this relationship is less well understood, and further research is warranted to investigate whether speech rhythm sensitivity predicts the different components of reading over time. In this 1-year longitudinal study, 69 five- to 8-year-old English-speaking children completed a speech rhythm assessment at Time 1 along with other cognitive assessments and then completed a variety of reading assessments at Time 2 (1 year later). A series of hierarchical regression analyses revealed that after controlling for individual differences in age, vocabulary, and phonological awareness, speech rhythm sensitivity was able to predict unique variance in word reading and the phrasing component of the reading fluency measure 1 year later. The findings emphasize the contribution of speech rhythm sensitivity in children’s reading development, and the authors argue that speech rhythm sensitivity should now be included in current models of children’s reading development. (PsycINFO Database Record (c) 2010 APA, all rights reserved)
from the Journal of Educational Psychology
Speech perception, metalinguistic awareness, reading, and vocabulary in Chinese–English bilingual children.
In this study, we examined the intercorrelations among speech perception, metalinguistic (i.e., phonological and morphological) awareness, word reading, and vocabulary in a 1st language (L1) and a 2nd language (L2). Results from 3 age groups of Chinese–English bilingual children showed that speech perception was more predictive of reading and vocabulary in the L1 than L2. While morphological awareness uniquely predicted reading and vocabulary in both languages, phonological awareness played such a role after we controlled for morphological awareness only in the L2, which was alphabetic. L1 speech perception and metalinguistic awareness predicted L2 word reading but not vocabulary, after we controlled for the corresponding L2 variables. Hence, there are both similarities and differences between the 2 languages in how the constructs are related. The differences are attributable to variations in language properties and learning contexts. Implications of the present results for an effective L2 learning program are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)
from the Journal of Educational Psychology
The contributions of phonological awareness and letter-name knowledge to letter-sound acquisition—a cross-classified multilevel model approach.
In the present study, we investigated critical factors in letter-sound acquisition (i.e., letter-name knowledge and phonological awareness) with data from 653 English-speaking kindergartners in the beginning of the year. We examined (a) the contribution of phonological awareness to facilitating letter-sound acquisition from letter names and (b) the probabilities of letter-sound acquisition as a function of letter characteristics (i.e., consonant–vowel letters, vowel–consonant letters, letters with no sound cues, and vowel letters). The results show that letter-name knowledge had a large impact on letter-sound acquisition. Phonological awareness had a larger effect on letter-sound knowledge when letter names were known than when letter names were unknown. Furthermore, students were more likely to know the sounds of consonant–vowel letters (e.g., b and d) than vowel–consonant letters (e.g., l and m) and letters with no sound cues (e.g., h and y) when the letter name was known and phonological awareness was accounted for. Sounds were least likely to be known for letters with no sound cues, but reliable differences from other groups of letters depended on students’ levels of phonological awareness and letter-name knowledge. (PsycINFO Database Record (c) 2010 APA, all rights reserved)
from the Journal of Educational Psychology
