PATU4 A population-based longitudinal study of cognitive and behavioural impairment in amyotrophic lateral sclerosis

Conclusion/relevance ALS is associated with a high prevalence of cognitive and behavioural change. The consensus guidelines facilitated categorisation of subgroups to track the evolution of cognitive and behavioural impairment over time but more rigorous validation is required prior their use in clinical practice. Those with normal cognitive function at baseline are less likely to develop dementia. Longitudinal studies are ongoing to confirm or refute whether ALS with cognitive impairment represents a distinct subpopulation of ALS or instead a continuum.

from the Journal of Neurosurgery

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