Dysfunction of bulbar central pattern generator in ALS patients with dysphagia during sequential deglutition
The corticobulbar control of swallowing is insufficient in ALS, and the swallowing CPG cannot work very well to produce segmental muscle activation and sequential swallowing. CPG dysfunction can result in irregular and arhythmical sequential swallowing in ALS patients with bulbar plus pseudobulbar types.
The arhythmical SWS pattern can be considered as a kind of dysfunction of CPG in human ALS cases with dysphagia.
Posted on May 26, 2011, in Research and tagged Central pattern generator, electrophysiology, Motor neuron disease, respiration, Sequential swallowing, Submental EMG. Bookmark the permalink. Leave a comment.