Blog Archives

Central auditory function in early Alzheimer’s disease and in mild cognitive impairment

our results demonstrate that central auditory processing dysfunction is highly evident in subjects with Alzheimer’s disease, and to a considerable extent even in subjects with mild cognitive impairment.

from Age and Ageing

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Auditory Pathways and Processes: Implications for Neuropsychological Assessment and Diagnosis of Children and Adolescents

Neuroscience research on auditory processing pathways and their behavioral and electrophysiological correlates has taken place largely outside the field of clinical neuropsychology. Deviations and disruptions in auditory pathways in children and adolescents result in a well-documented range of developmental and learning impairments frequently referred for neuropsychological evaluation. This review is an introduction to research from the last decade. It describes auditory cortical and subcortical pathways and processes and relates recent research to specific conditions and questions neuropsychologists commonly encounter. Auditory processing disorders’ comorbidity with ADHD and language-based disorders and research addressing the challenges of assessment and differential diagnosis are discussed.

from Child Neuropsychology

Abnormal pattern of cortical speech feature discrimination in six-year-old children at-risk for dyslexia

The present study aimed to determine whether speech-sound encoding and discrimination are affected in 6-year-old children having an elevated risk for dyslexia. Their event-related potentials (ERPs) for syllables and syllable changes critical in speech perception and language development (vowel, vowel-duration, consonant, frequency (F0), and intensity changes) were compared with those of children without a dyslexia risk. ERPs were recorded with a new linguistic multi-feature paradigm which enables one to assess the discrimination of five features in 20 min. Also, an oddball condition with vowel and vowel-duration deviants was included. The amplitudes of the P1 response elicited by the standard stimuli were smaller in the at-risk group. Furthermore, the amplitudes of the mismatch negativity (MMN) were smaller for the vowel, vowel-duration, consonant, and intensity deviants in children at-risk for dyslexia. These results are consistent with earlier studies reporting auditory processing difficulties in children at-risk for dyslexia and diagnosed dyslexia. However, the current study, enabling the recording of MMN for multiple sound features, suggests the presence of wide-spread auditory difficulties in children at-risk for dyslexia.

from Brain Research

Auditory discrimination profiles of speech sound changes in 6-year-old children as determined with the multi-feature MMN paradigm

Conclusions
The new time-efficient paradigm can be used in studies addressing cortical speech-sound discrimination in young children.

Significance
The multi-feature paradigm enables fast (20min) recording of MMNs for five speech-sound features. In future, it might be useful in detecting abnormalities in speech discrimination profiles of children with possible language-related disorders.

from Clinical Neurophysiology