Blog Archives

Cluster analysis of auditory and vestibular test results in definite menière’s disease

Conclusions:
We have identified four distinct profiles of patients with definite Menière’s disease that we consider as “mildly active elderly,” “mildly active young,” “active compensated,” and “active uncompensated.” We have demonstrated that only in a restricted population of patients can the American Academy of Otolaryngology–Head and Neck Surgery staging system provide analysis of subtypes of the disease.

from The Laryngoscope

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The mitochondrial A3243G mutation involves the peripheral vestibule as well as the cochlea

Conclusions:
The A3243G mutation is associated with vestibular dysfunction involving both the superior and inferior vestibular nerve systems. Furthermore, our results from galvanic-VEMP testing suggests that a labyrinthine lesion is primarily responsible for the symptoms of vestibular dysfunction

from The Laryngoscope

The grainyhead-like 2 gene (GRHL2) single nucleotide polymorphism is not associated with age-related hearing impairment in han Chinese

Conclusions:
Our results showed no positive association between GRHL2 polymorphisms and ARHI in Han Chinese individuals. Population differences might be a key factor leading to nonreplication of the association.

from The Laryngoscope

Phenotype of the first otosclerosis family linked to OTSC10†

The intersubject variation, in terms of age of onset, level of progression, and audiogram configuration, was remarkable, probably due to reduced penetrance and variable expression of the disease. Long-term audiometric data in one patient, however, were useful to demonstrate progression of hearing impairment. Laryngoscope, 2011

from The Laryngoscope

Hearing assessment in Menière’s disease†

In Menière’s disease, audiometry results corrected for patient age show an inherent upward-sloping configuration of the mean audiometric curve at all time points during the disease. The hearing pattern differs between unilateral and bilateral disease. The audiometric curve configuration may be an indicator of future bilateral disease. Laryngoscope, 2011

from The Laryngoscope

Temporal bone abnormalities in children with GJB2 mutations

Conclusions:
Our study of 113 biallelic GJB2 patients with SNHL and temporal bone imaging is the largest study to date. We found only 10% had any abnormalities, most subtle, and none had EVA. Additionally, there was no correlation between SNHL severity and presence/absence/type of malformations or genotype. Disparities between our group and previous reports may be due to differences in degree of hearing loss, types of mutations, populations studied, and radiologic factors for both image acquisition and interpretation.

from The Laryngoscope

Botulinum toxin treatment of adductor spasmodic dysphonia: Longitudinal functional outcomes

Conclusions:
It is important to consider longitudinal functional outcomes in BoNT treatment of AdSD. An individuated dosing regimen helps minimize side effects and maximize functional and quality-of-life outcomes.

from The Laryngoscope

Postcricoid vascular lesions Histopathological and Immunohistochemical Diagnosis

Conclusions:
Patients with postcricoid vascular lesions usually present with mild to moderate feeding difficulties, and stridor or dyspnea with agitation. Histopathology and immunohistochemistry results suggest that postcricoid vascular lesions may often represent congenital vascular malformations instead of infantile hemangiomas.

from The Laryngoscope

Zinc in the treatment of idiopathic sudden sensorineural hearing loss

Zinc supplementation may enhance the hearing recovery of SSNHL patients. Its antioxidant and anti-inflammatory effects may help reduce the oxidative stress of the cochlea in SSNHL, implying a new direction in the treatment of this disease.

from The Laryngoscope

Cochlear implantation in children with enlarged vestibular aqueduct

Children with EVA undergoing cochlear implantation are at greater risk for CSF gushers, but they do well audiometrically and functionally. Laryngoscope, 2010

from The Laryngoscope

Effect of cricopharyngeus muscle surgery on the pharynx

Relief of CP obstruction by surgery or dilation improves pharyngeal constriction and PES opening. Dilation of the pharynx possibly related to prolonged outlet obstruction does not improve. CP myotomy appears more effective than dilation or botulinum toxin in relieving obstruction.

from The Laryngoscope