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Dysfunction of bulbar central pattern generator in ALS patients with dysphagia during sequential deglutition

Conclusions
The corticobulbar control of swallowing is insufficient in ALS, and the swallowing CPG cannot work very well to produce segmental muscle activation and sequential swallowing. CPG dysfunction can result in irregular and arhythmical sequential swallowing in ALS patients with bulbar plus pseudobulbar types.

Significance
The arhythmical SWS pattern can be considered as a kind of dysfunction of CPG in human ALS cases with dysphagia.

from Clinical Neurophysiology